Microphysiological system as a promising technology for drug assay

Human Vascular Microphysiological System for in vitro Drug Screening.

In vitro human tissue engineered human blood vessels (TEBV) that exhibit vasoactivity can be used to test human toxicity of pharmaceutical drug candidates prior to pre-clinical animal studies. TEBVs with 400-800 μM diameters were made by embedding human neonatal dermal fibroblasts or human bone marrow-derived mesenchymal stem cells in dense collagen gel. TEBVs were mechanically strong enough to...

Camphor as a promising insecticude for control

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

Drug discovery and development are hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing. A fundamental problem in this inefficient process is that non-human animal models cannot adequately represent human biology. Thus, there is an urgent need for high-content in vitro systems that can better predict drug-induced toxici...

Microspheres as a Promising Mucoadhesive Drug Delivery System - Review

International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net 8 Swapna. S*, Dr. Anna Balaji, Dr. M.S Uma Shankar, A.Vijendar Department of Pharmaceutics, Trinity College of Pharmaceutical Sciences, Karimnagar, Andhra Pradesh, India. Department of Pharmaceutics, Sree Datha Institute of Pharmacy, Ibrahimpatnam, Hyderabad, Andhra Pradesh, Ind...

A Review on Current Status and Future Potential of Transdermal Patches as a Promising Drug Delivery System

Transdermal patches are now widely used in topical and transdermal drug delivery systems (TDDS). Up to now, TDDS has been used in several conditions, such as smoking cessation, analgesic effect, nausea, contraception, and hormone therapy. Basically, there are two types of transdermal patches: the reservoir-type patches and the matrix-type patches. First generation TDDS were designed for deliver...